Case series in NEJM - early US ICU experience with COVID19 out of Seattle. 24 patients admitted with respiratory failure, most requiring vasopressor support. Mortality a striking 50% with 7 patients still hospitalized at press

A small study from a group of 24 critically ill patients in Seattle. Paper here

Case series in @NEJM - early US ICU experience with #COVID19 out of Seattle. 24 patients admitted with respiratory failure, most requiring vasopressor support. Mortality a striking 50% with 7 patients still hospitalized at press. #StayAtHome https://t.co/0NQ1KLSfBN

— Stephen V Liu (@StephenVLiu) April 2, 2020

Outcomes at the end of the study:

• 50% (12 of 24) died between after 1 to 18 days in ICU
• 5 patients were discharged home
• 4 were discharged from ICU but remain hospitalizeed
• 3 remain on mechaical ventilation

This was the timeline for the patients

Only 50% had fever on admission.

Analysis: the most common presenting symptoms were shortness of breath and cough, which all patients had. Only 50% had a documented fever, though.https://t.co/yNUCRz8A7s

— Rick Keller (@RickKellerMD) March 31, 2020

Imaging showed infiltrates in all patients.

CT of a patient with ARDS:

Over half had diabetes and higher than average BMI, but as this doctor notes it’s a small group with preliminary data.

New report of critically ill Covid-19 patients near Seattle.

👉More than half had diabetes.

👉Average body mass index 33 (well above the national average of about 28 to 29).

This is a small group, and data are preliminary, so we can't make any conclusions, but concerning. https://t.co/44AqHM4pPH pic.twitter.com/EebWMi6IFY

— Dr. David Ludwig (@davidludwigmd) March 31, 2020

Detailed baseline data on these patients

Therapies and outcomes: note the high level of vasopressors